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Attention Score in Context
| Title |
Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
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|---|---|
| Published in |
FASEB Journal, July 2013
|
| DOI | 10.1096/fj.12-224048 |
| Pubmed ID | |
| Authors |
Tod Fullston, E. Maria C. Ohlsson Teague, Nicole O. Palmer, Miles J. DeBlasio, Megan Mitchell, Mark Corbett, Cristin G. Print, Julie A. Owens, Michelle Lane |
| Abstract |
Obesity is highly prevalent, and its incidence is increasing. The previous study showing a major effect of paternal obesity on metabolic health of offspring is confounded by comorbidity with diabetes. Therefore, we investigated the effect of diet-induced paternal obesity, in the absence of diabetes, on the metabolic health of two resultant generations and the molecular profiles of the testes and sperm. Founder (F0) male C57BL6 mice were fed either a high-fat diet (HFD) or a control diet (CD); n = 10/diet for a period of 10 wk. Testis expression of mRNA/microRNAs was analyzed by microarray and qPCR and sperm microRNA abundance by qPCR. Two subsequent generations were generated by mating F0 and then F1 mice to CD mice, and their metabolic health was investigated. All mice, other than F0 males, were maintained on a CD. HFD feeding induced paternal obesity with a 21% increase in adiposity, but not overt diabetes, and initiated intergenerational transmission of obesity and insulin resistance in two generations of offspring. This distinct phenotypic constellation is either partially or fully transmitted to both female and male F1 offspring and further transmitted through both parental lineages to the F2 generation, with a heightened effect on female F1 offspring (+67% in adiposity) and their F2 sons (+24% in adiposity). Founder male obesity altered the testes expression of 414 mRNAs by microarray and 11 microRNAs by qPCR, concomitant with alterations in sperm microRNA content and a 25% reduction in global methylation of germ cell DNA. Diet-induced paternal obesity modulates sperm microRNA content and germ cell methylation status, which are potential signals that program offspring health and initiate the transmission of obesity and impaired metabolic health to future generations. This study implicates paternal obesity in the transgenerational amplification of obesity and type 2 diabetes in humans. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 12% |
| Peru | 1 | 6% |
| Spain | 1 | 6% |
| Australia | 1 | 6% |
| Canada | 1 | 6% |
| South Africa | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 9 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Practitioners (doctors, other healthcare professionals) | 3 | 18% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 379 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 3 | <1% |
| United Kingdom | 2 | <1% |
| Chile | 2 | <1% |
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Israel | 1 | <1% |
| Netherlands | 1 | <1% |
| Finland | 1 | <1% |
| Canada | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 364 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 18% |
| Researcher | 55 | 15% |
| Student > Bachelor | 53 | 14% |
| Student > Master | 52 | 14% |
| Student > Doctoral Student | 27 | 7% |
| Other | 55 | 15% |
| Unknown | 68 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 105 | 28% |
| Biochemistry, Genetics and Molecular Biology | 81 | 21% |
| Medicine and Dentistry | 49 | 13% |
| Neuroscience | 19 | 5% |
| Psychology | 7 | 2% |
| Other | 32 | 8% |
| Unknown | 86 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 145. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2021.
All research outputs
#289,450
of 25,837,817 outputs
Outputs from FASEB Journal
#89
of 11,606 outputs
Outputs of similar age
#1,916
of 208,570 outputs
Outputs of similar age from FASEB Journal
#2
of 72 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,606 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,570 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.