↓ Skip to main content

FASEB

Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism

Overview of attention for article published in FASEB Journal, February 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 11,475)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
10 news outlets
blogs
5 blogs
twitter
256 X users
facebook
27 Facebook pages
wikipedia
3 Wikipedia pages
googleplus
10 Google+ users
reddit
3 Redditors
video
8 YouTube creators

Citations

dimensions_citation
300 Dimensions

Readers on

mendeley
539 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
Published in
FASEB Journal, February 2014
DOI 10.1096/fj.13-246546
Pubmed ID
Authors

Rhonda P. Patrick, Bruce N. Ames

Abstract

Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE. The proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier; the low concentrations of the vitamin D hormone precursor 25-hydroxyvitamin D [25(OH)D3]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. Two peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.-Patrick, R. P., Ames, B. N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism.

X Demographics

X Demographics

The data shown below were collected from the profiles of 256 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 539 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
Netherlands 2 <1%
United Kingdom 2 <1%
Brazil 1 <1%
Denmark 1 <1%
Germany 1 <1%
Spain 1 <1%
Croatia 1 <1%
Unknown 526 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 91 17%
Student > Master 81 15%
Researcher 68 13%
Student > Ph. D. Student 48 9%
Other 40 7%
Other 96 18%
Unknown 115 21%
Readers by discipline Count As %
Medicine and Dentistry 120 22%
Agricultural and Biological Sciences 54 10%
Biochemistry, Genetics and Molecular Biology 50 9%
Psychology 42 8%
Nursing and Health Professions 37 7%
Other 107 20%
Unknown 129 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 328. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2024.
All research outputs
#102,665
of 25,542,788 outputs
Outputs from FASEB Journal
#30
of 11,475 outputs
Outputs of similar age
#806
of 239,290 outputs
Outputs of similar age from FASEB Journal
#1
of 108 outputs
Altmetric has tracked 25,542,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,475 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.