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Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells

Overview of attention for article published in FASEB Journal, December 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 11,453)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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Title
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells
Published in
FASEB Journal, December 2014
DOI 10.1096/fj.14-259598
Pubmed ID
Authors

Christopher S. Reigstad, Charles E. Salmonson, John F. Rainey, Joseph H. Szurszewski, David R. Linden, Justin L. Sonnenburg, Gianrico Farrugia, Purna C. Kashyap

Abstract

Gut microbiota alterations have been described in several diseases with altered gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut microbiome in modulating GI function. Serotonin [5-hydroxytryptamine (5-HT)] is a key regulator of GI motility and secretion. To determine the relationship among gut microbes, colonic contractility, and host serotonergic gene expression, we evaluated mice that were germ-free (GF) or humanized (HM; ex-GF colonized with human gut microbiota). 5-HT reduced contractile duration in both GF and HM colons. Microbiota from HM and conventionally raised (CR) mice significantly increased colonic mRNAs Tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-HT synthesis; P < 0.01] and chromogranin A (neuroendocrine secretion; P < 0.01), with no effect on monoamine oxidase A (serotonin catabolism), serotonin receptor 5-HT4, or mouse serotonin transporter. HM and CR mice also had increased colonic Tph1 protein (P < 0.05) and 5-HT concentrations (GF, 17 ± 3 ng/mg; HM, 25 ± 2 ng/mg; and CR, 35 ± 3 ng/mg; P < 0.05). Enterochromaffin (EC) cell numbers (cells producing 5-HT) were unchanged. Short-chain fatty acids (SCFAs) promoted TPH1 transcription in BON cells (human EC cell model). Thus, gut microbiota acting through SCFAs are important determinants of enteric 5-HT production and homeostasis.-Reigstad, C. S., Salmonson, C. E., Rainey, III, J. F., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., Kashyap, P. C. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 876 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Netherlands 1 <1%
France 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 870 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 137 16%
Student > Ph. D. Student 127 14%
Researcher 97 11%
Student > Master 93 11%
Student > Doctoral Student 44 5%
Other 127 14%
Unknown 251 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 133 15%
Biochemistry, Genetics and Molecular Biology 127 14%
Medicine and Dentistry 87 10%
Immunology and Microbiology 52 6%
Neuroscience 49 6%
Other 142 16%
Unknown 286 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 478. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#55,771
of 25,394,764 outputs
Outputs from FASEB Journal
#13
of 11,453 outputs
Outputs of similar age
#496
of 359,703 outputs
Outputs of similar age from FASEB Journal
#1
of 101 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,453 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,703 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.