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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transgenerational epigenetic inheritance in mammals: how good is the evidence?
|
|---|---|
| Published in |
FASEB Journal, April 2016
|
| DOI | 10.1096/fj.201500083 |
| Pubmed ID | |
| Authors |
Sanne D. van Otterdijk, Karin B. Michels |
| Abstract |
Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are modified throughout life in response to environmental and behavioral influences. With each new generation, DNA methylation patterns are erased in gametes and reset after fertilization, probably to prevent these epigenetic marks from being transferred from parents to their offspring. However, some recent animal studies suggest an apparent resistance to complete erasure of epigenetic marks during early development, enabling transgenerational epigenetic inheritance. Whether there are similar mechanisms in humans remains unclear, with the exception of epigenetic imprinting. Nevertheless, a distinctly different mechanism-namely, intrauterine exposure to environmental stressors that may affect establishment of the newly composing epigenetic patterns after fertilization-is often confused with transgenerational epigenetic inheritance. In this review, we delineate the definition of and requirement for transgenerational epigenetic inheritance, differentiate it from the consequences of intrauterine exposure, and discuss the available evidence in both animal models and humans.-Van Otterdijk, S. D., Michels, K. B. Transgenerational epigenetic inheritance in mammals: how good is the evidence? |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 17% |
| United Kingdom | 1 | 6% |
| South Africa | 1 | 6% |
| Australia | 1 | 6% |
| France | 1 | 6% |
| United States | 1 | 6% |
| Unknown | 10 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 67% |
| Scientists | 5 | 28% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 371 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 366 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 68 | 18% |
| Student > Bachelor | 53 | 14% |
| Student > Master | 47 | 13% |
| Researcher | 44 | 12% |
| Student > Postgraduate | 35 | 9% |
| Other | 54 | 15% |
| Unknown | 70 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 113 | 30% |
| Agricultural and Biological Sciences | 96 | 26% |
| Medicine and Dentistry | 21 | 6% |
| Psychology | 12 | 3% |
| Neuroscience | 9 | 2% |
| Other | 37 | 10% |
| Unknown | 83 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2022.
All research outputs
#1,178,104
of 25,477,125 outputs
Outputs from FASEB Journal
#521
of 11,472 outputs
Outputs of similar age
#20,201
of 314,934 outputs
Outputs of similar age from FASEB Journal
#8
of 123 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,472 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,934 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.